"Blend of Michael and -lene"
The name Michalene is commonly a female name from the "English" origin.
Michalene is an English feminine name built from Michael with the -lene ending that also appears in Marlene, Charlene and Darlene. The root, Michael, is a Hebrew name. Michalene has no independent meaning of its own beyond that root.
The pronunciation of Michalene is mik-uh-LEEN.