"Blend of La- and Wayne"
The name Lawayne is commonly a male name from the "American" origin.
Lawayne is formed by placing the prefix La- in front of the English given name Wayne, a pattern that also appears in American names such as Laverne and LaDonna. Wayne comes from an English surname, which surname dictionaries trace to the Old English word waegn, meaning wagon or cart. The name has no separate meaning of its own beyond that of Wayne.
The pronunciation of Lawayne is luh-WAYN.